Autor(es): Reis, Alexandre Barbosa ; Martins Filho, Olindo Assis ; Carvalho, Andréa Teixeira de ; Carvalho, Maria das Graças ; Mayrink, Wilson ; Silva, João Carlos França da ; Giunchetti, Rodolfo Cordeiro ; Genaro, Odair ; Oliveira, Rodrigo Corrêa de
Data: 2012
Origem: Oasisbr
Assunto(s): Canine visceral leishmaniasis; Leishmania infantum; Parasite density; Biochemical/hematological status
We have performed a detailed investigation in 40 dogs naturally infected withLeishmania infantum ( syn. chagasi), subdivided into three groups: asymptomatic (AD = 12), oligosymptomatic (OD = 12) and symptomatic (SD = 16), based on their clinical features. Twenty non-infected dogs (CD) were included as control group. Serological analysis, performed by IFAT and ELISA, demonstrated higher antibodies titers in SD in comparison to the AD. A positive correlation was found between parasite density in the spleen and skin smears as well as the bone marrow parasitism with clinical status of the infection. We observed that the progression of the disease from asymptomatic to symptomatic clinical form was accompanied by intense parasitism in the bone marrow. It is likely that this led to the impaired biochemical/hematological status observed. Finally, we believe that the follow-up of these parameters could be a relevant approach to be used as markers during therapeutic and vaccine evaluations.
