Autor(es):
Gomes, André ; Farias, Guilherme B. ; Dias Silva, Manuel ; Laia, Joel ; Trombetta, Amelia Chiara ; Godinho-Santos, Ana ; Rosmaninho, Pedro ; Santos, Diana F. ; Conceição, Carolina M. ; Costa Reis, Renato ; Adao-Serrano, Maria ; Mota, Catarina ; Almeida, Afonso ; Sousa, Ana E. ; Fernandes, Susana M.
Data: 2021
Identificador Persistente: http://hdl.handle.net/10451/57633
Origem: Repositório da Universidade de Lisboa
Assunto(s): CCR10; COVID-19; Innate lymphoid cells; Lung recovery; SARS-CoV2
Descrição
Accelerate lung repair in SARS-CoV-2 pneumonia is essential for pandemic handling. Innate lymphoid cells (ILCs) are likely players, given their role in mucosal protection and tissue homeostasis. We studied ILC subpopulations at two time points in a cohort of patients admitted in the hospital due to SARS-CoV-2 infection. COVID-19 patients with moderate/severe respiratory failure featured profound depletion of circulating ILCs at hospital admission, in agreement with overall lymphocyte depletion. However, ILCs recovered in direct correlation with lung function improvement as measured by oxygenation index and in negative association with inflammatory and lung/endothelial damage markers like RAGE. While both ILC1 and ILC2 expanded, ILC2 showed the most striking phenotype changes, with CCR10 upregulation in strong correlation with these parameters. Overall, CCR10+ ILC2 emerge as relevant contributors to SARS-CoV-2 pneumonia recovery.
