Author(s): Custódio, Charllyany Sabino ; Mello, Bruna Stefânia Ferreira ; Chaves Filho, Adriano José Maia ; Lima, Camila Nayane de Carvalho ; Cordeiro, Rafaela Carneiro ; Miyajima, Fábio Miyajima ; Vasconcelos, Silvânia Maria Mendes ; Barichello, Tatiana ; Quevedo, João ; Oliveira, Antônio Carlos de ; Lucena, David Freitas de ; Réus, Gislaine Z. ; Macedo, Danielle S.
Date: 2017
Origin: Oasisbr
Subject(s): Caracteres Sexuais; Sex Differences; Autismo
Early-life challenges, particularly infections and stress, are related to neuropsychiatric disorders such as autism and schizophrenia. Here, we conducted a wide range of behavioral tests in periadolescent (postnatal day (PN) 35) and adult (PN70) Swiss mice neonatally challenged with LPS on PN5 and -7, to unveil behavioral alterations triggered by LPS exposure. Immune and neurotrophic (brain-derived neurotrophic factor—BDNF) alterations were determined in the prefrontal cortex (PFC), hippocampus (HC), and hypothalamus (HT). Since the incidence and clinical manifestations of neurodevelopmental disorders present significant sex-related differences, we sought to distinctly evaluate male and female mice. While on PN35, LPS-challenged male mice presented depressive, anxiety-like, repetitive behavior, and working memory deficits; on PN70, only depressive- and anxiety-like behaviors were observed. Conversely, females presented
