Author(s):
Caetano, Érica Pacheco ; Cordeiro, Rossana de Aguiar ; Marques, Francisca Jakelyne de Farias ; Brilhante, Raimunda Sâmia Nogueira ; Silva, Kylvia Rocha de Castro e ; Mourão, Charles Ielpo ; Fechine, Maria Auxiliadora Bezerra ; Ribeiro, Joyce Fonteles ; Castelo-Branco, Débora de Souza Collares Maia ; Lima, Rita Amanda Chaves de ; Rocha, Jacó Ricarte Castro ; Rocha, Marcos Fábio Gadelha ; Sidrim, José Júlio Costa ; Mesquita, Jacó Ricarte Lima ; Monteiro, Andre Jalles
Date: 2013
Origin: Oasisbr
Subject(s): Antibióticos Antituberculose; Azóis; Histoplasma
Description
This study evaluated in vitro interactions of antituberculosis drugs and triazoles against Histoplasma capsulatum. Nine drug combinations, each including an antituberculosis drug (isoniazid, pyrazinamide, or ethambutol) plus a triazole (itraconazole, fluconazole, or voriconazole), were tested against both growth forms of H. capsulatum. Stronger synergistic interactions were seen in isoniazid or pyrazinamide plus triazoles for the mold form and ethambutol plus voriconazole for the yeast-like form. Further studies should evaluate these combinations in vivo.
