Autor(es): Salehi, B ; Upadhyay, S ; Orhan, IE ; Jugran, AK ; Jayaweera, SLD ; Dias, D ; Sharopov, F ; Taheri, Y ; Martins, N ; Baghalpour, N ; Cho, WC ; Sharifi-Rad, J
Data: 2019
Identificador Persistente: https://hdl.handle.net/10216/138970
Origem: Repositório Aberto da Universidade do Porto
a-and ß-pinene are well-known representatives of the monoterpenes group, and are found in many plants’ essential oils. A wide range of pharmacological activities have been reported, including antibiotic resistance modulation, anticoagulant, antitumor, antimicrobial, antimalarial, antioxidant, anti-inflammatory, anti-Leishmania, and analgesic effects. This article aims to summarize the most prominent effects of a-and ß-pinene, namely their cytogenetic, gastroprotective, anxiolytic, cytoprotective, anticonvulsant, and neuroprotective effects, as well as their effects against H2O2-stimulated oxidative stress, pancreatitis, stress-stimulated hyperthermia, and pulpal pain. Finally, we will also discuss the bioavailability, administration, as well as their biological activity and clinical applications.
