Author(s):
Correia Guedes, Leonor ; Reimão, Sofia ; Paulino, Patrícia ; Nunes, Rita G. ; Bouça-Machado, Raquel ; Abreu, Daisy ; Gonçalves, Nilza ; Soares, Tiago ; Fabbri, Margherita ; Godinho, Catarina ; Pita Lobo, Patrícia ; Neutel, Dulce ; Quadri, Marialuisa ; Coelho, Miguel ; Rosa, Mário Miguel ; Campos, Jorge ; Outeiro, Tiago ; Sampaio, Cristina ; Bonifati, Vincenzo ; Ferreira, Joaquim J
Date: 2017
Persistent ID: http://hdl.handle.net/10451/54389
Origin: Repositório da Universidade de Lisboa
Description
Specific T-weighted MRI sequences are able to detect SN neuromelanin (NM) signal changes and accurately discriminate Parkinson’s disease (PD) patients from controls. The study of NM-MRI in PD patients carrying a LRRK2 gene mutation (LRRK2-PD) could contribute to further uncover LRRK2-associated phenotype. Albeit considered to largely overlap idiopathic PD (iPD), differences have been described. Furthermore, the identification of a biomarker of neurodegeneration in LRRK2-PD can eventually support studies in asymptomatic carriers. Castellanos and colleagues5 found NM-MRI SN volumes significantly reduced in both idiopathic and LRRK2-PD (3 G2019S and 4 R1441G PD patients).
