Document details

IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity

Author(s): Cunha, Cristina ; Gonçalves, Samuel M. ; Duarte-Oliveira, Claudio ; Leite, Luis ; Lagrou, Katrien ; Marques, António ; Lupianez, Carmen B. ; Mesquita, Inês ; Gaifem, Joana ; Barbosa, Ana Margarida ; Vaz, Carlos Pinho ; Branca, Rosa ; Campilho, Fernando ; Freitas, Fatima ; Ligeiro, Dario ; Lass-Floerl, Cornelia ; Loffler, Jurgen ; Jurado, Manuel ; Saraiva, Margarida ; Kurzai, Oliver ; Rodrigues, Fernando ; Castro, António G. ; Silvestre, Ricardo ; Sainz, Juan ; Maertens, Johan A. ; Torrado, Egídio ; Jacobsen, Ilse D. ; Lacerda, Joao F. ; Campos, Antonio, Jr. ; Carvalho, Agostinho

Date: 2017

Persistent ID: http://hdl.handle.net/1822/67150

Origin: RepositóriUM - Universidade do Minho

Subject(s): Adult; Aspergillosis; Female; Hematopoietic Stem Cell Transplantation; Humans; Interleukin-10; Leukocytes, Mononuclear; Macrophages; Male; Polymorphism, Single Nucleotide; Young Adult; Genetic Predisposition to Disease; Science & Technology


Description

[Excerpt] To the Editor: Proinflammatory immune responses are critically required for antimicrobial host defenses; however, excessive inflammation has the potential to damage host tissues thereby paradoxically contributing to the progression of infection.[...]

Supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (NORTE-01-0145-FEDER-000013), the Fundacao para a Ciencia e Tecnologia (FCT) (contracts IF/00735/2014 to A.C., IF/01390/2014 to E.T., IF/00021/2014 to R.S., and SFRH/BPD/96176/2013 to C.C.), the Conselho de Reitores das Universidades Portuguesas (CRUP), Portugal (Acoes Integradas Luso-Alemas A-43/16), the Deutscher Akademischer Austauschdienst (DAAD) (project-ID 57212690), the Fondo de Investigaciones Sanitarias (Madrid, Spain) (grant #PI12/02688) and the ERA-NET PathoGenoMics (grant #0315900A). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Document Type Letter to the editor
Language English
Contributor(s) Universidade do Minho
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