Autor(es): Sharifi-Rad, J ; Rodrigues, CF ; Sharopov, F ; Docea, AO ; Karaca, AC ; Sharifi-Rad, M ; Karincaoglu, DK ; Gülseren, G ; Senol, E ; Demircan, E ; Taheri, Y ; Suleria, HAR ; Özçelik, B ; Kasapoglu, KN ; Gültekin-Özgüven, M ; Daskaya-Dikmen, C ; Cho, WC ; Martins, N ; Calina, D
Data: 2020
Identificador Persistente: https://hdl.handle.net/10216/142507
Origem: Repositório Aberto da Universidade do Porto
Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumption of plant-food bioactive derivatives including polyphenolic compounds, peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on cardiovascular diseases. This review aims to summarize the cardiovascular risk factors, pre-clinical studies and clinical trials related to cardioprotective properties of the plant-food-derived bioactive compounds. Molecular mechanisms by the natural bioactive compounds exert their cardiovascular protective properties have also been highlighted.
